Chemical Carcinogenesis: A Review

Chemical carcinogenesis; a review.

Chenistry of Carcinogenic Compounds The first of the eighteen articles, which is by Haddow and Kon, on the chemistry of carcinogenic compounds1 begins with Percival Pott (1775) and leads the history of the subject via Yamagiwa to Kennaway's work on synthetic tars (Kennaway, 1924, 1925; Kennaway and Hieger,. 1930) and his discoveryt of the first cancer producing hydrocarbon, I: 2: 5: 6-dibenzant...

Advances in Chemical Carcinogenesis: A Historical Review

Advances in chemical carcinogenesis: a historical review and prospective.

The American Association for Cancer Research has been the citadel for communicating research on chemical carcinogens for over a century. It therefore seems appropriate that a review of chemical carcinogenesis inaugurates a series of articles highlighting advances in understanding, treating, and preventing cancer. At the dawn of the 20th century, we had recognized that chemicals cause cancer, bu...

Chemical carcinogenesis.

The use of chemical compounds benefits society in a number of ways. Pesticides, for instance, enable foodstuffs to be produced in sufficient quantities to satisfy the needs of millions of people, a condition that has led to an increase in levels of life expectancy. Yet, at times, these benefits are offset by certain disadvantages, notably the toxic side effects of the chemical compounds used. E...

Environmental and chemical carcinogenesis.

People are continuously exposed exogenously to varying amounts of chemicals that have been shown to have carcinogenic or mutagenic properties in experimental systems. Exposure can occur exogenously when these agents are present in food, air or water, and also endogenously when they are products of metabolism or pathophysiologic states such as inflammation. It has been estimated that exposure to...